The AU565 breast carcinoma cell line was used to determine the role of the extracellular-regulated kinase (ERK) pathway in mediating Heregulin1 (HRG1)-induced mammary cell differentiation. ERK activation remained elevated for 2 h following high doses of HRG which induce differentiation. In contras
✦ LIBER ✦
Regulation of extracellular signal-regulated kinases (ERKs) by naloxone-induced morphine withdrawal in the brain stress system
✍ Scribed by Cristina Núñez; M. Teresa Castells; M. Luisa Laorden; M. Victoria Milanés
- Publisher
- Springer-Verlag
- Year
- 2008
- Tongue
- English
- Weight
- 478 KB
- Volume
- 378
- Category
- Article
- ISSN
- 0028-1298
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## Abstract Recent studies have shown that MEK/ERK‐mediated signals play a major role in regulation of activity of p53 tumor suppressor protein. In this study, we investigated whether or not there is functional interaction between p53 and MEK/ERK pathways in epithelial breast cancer cells exposed t