𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Regulation of epithelial permeability by the actin cytoskeleton

✍ Scribed by Laurel S. Rodgers; Alan S. Fanning

Publisher
Wiley (John Wiley & Sons)
Year
2011
Tongue
English
Weight
107 KB
Volume
68
Category
Article
ISSN
1949-3584

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The actin cytoskeleton is a dynamic structure necessary for cell and tissue organization, including the maintenance of epithelial barriers. The epithelial barrier regulates the movement of ions, macromolecules, immune cells, and pathogens, and is thus essential for normal organ function. Disruption in the epithelial barrier has been shown to coincide with alterations of the actin cytoskeleton in several disease states. These disruptions primarily manifest as increased movement through the paracellular space, which is normally regulated by tight junctions (TJ). Despite extensive research demonstrating a direct link between the actin cytoskeleton and epithelial permeability, our understanding of the physiological mechanisms that link permeability and tight junction structure are still limited. In this review, we explore the role of the actin cytoskeleton at TJ and present several areas for future study. Β© 2011 Wiley Periodicals, Inc

πŸ“œ SIMILAR VOLUMES

Regulation of chondrocyte differentiatio
Regulation of chondrocyte differentiation by the actin cytoskeleton and adhesive interactions
✍ Anita Woods; Guoyan Wang; Frank Beier πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 223 KB

## Abstract Chondrocyte differentiation is a multi‐step process characterized by successive changes in cell morphology and gene expression. In addition to tight regulation by numerous soluble factors, these processes are controlled by adhesive events. During the early phase of the chondrocyte life

Relationships between the actin cytoskel
Relationships between the actin cytoskeleton and cell volume regulation
✍ Henson, John H. πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 262 KB πŸ‘ 2 views

The actin cytoskeleton mediates a variety of essential biological functions in cells, including division, shape changes, and movement. A number of studies have suggested that the abundant submembranous actin cytoskeleton present in the cortex of many cell types is involved in the regulation of cell

Regulation of plasma membrane blebbing b
Regulation of plasma membrane blebbing by the cytoskeleton
✍ JΓΆrg Hagmann; Max M. Burger; Daniel Dagan πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 332 KB πŸ‘ 2 views

When neuroblastoma cells are exposed to lysophosphatidic acid (LPA), they undergo a vigorous, but transient blebbing phase. The effect is sensitive to inhibition by staurosporine, KT 5926 (an inhibitor of myosin light chain kinase), and cytochalasin B, suggesting that LPA activates the phosphorylati

Role of the actin cytoskeleton in insuli
Role of the actin cytoskeleton in insulin action
✍ Tsakiridis, Theodoros; Tong, Peter; Matthews, Benjamin; Tsiani, Evangelia; Bilan πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 419 KB πŸ‘ 2 views

Insulin has diverse effects on cells, including stimulation of glucose transport, gene expression, and alterations of cell morphology. The hormone mediates these effects by activation of signaling pathways which utilize, 1) adaptor molecules such as the insulin receptor substrates (IRS), the Src and

Genetic connections of the actin cytoske
Genetic connections of the actin cytoskeleton and beyond
✍ Piergiorgio Percipalle πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 160 KB πŸ‘ 1 views

## Abstract Actin is a key protein in numerous cellular functions. One recent study has identified a large set of genes, associated with the actin cytoskeleton, which could be grouped into a wide spectrum of cytoplasmic and nuclear functions, such as protein biosynthesis and gene transcription.1 De