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Regulation of Epidermal Growth Factor Receptor Internalization by G Protein-Coupled Receptors †

✍ Scribed by Kim, Jihee; Ahn, Seungkirl; Guo, Rishu; Daaka, Yehia


Book ID
126179226
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
387 KB
Volume
42
Category
Article
ISSN
0006-2960

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The receptor for epidermal growth factor (EGF) is a glycosylated transmembrane phosphoprotein that exhibits EGF-stimulable protein tyrosine kinase activity. On EGF stimulation, the receptor undergoes a self-phosphorylation reaction at tyrosine residues located primarily in the extreme carboxyl-termi