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Regulation of endothelin-1 production by a thromboxane A2 mimetic in rat heart smooth muscle cells

✍ Scribed by Chu Chang Chua; Ronald C. Hamdy; Balvin H.L. Chua


Book ID
116106445
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
537 KB
Volume
1313
Category
Article
ISSN
0167-4889

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Two important mediators of endothelium-dependent regulation of vascular smooth muscle tone and proliferation are nitric oxide (NO) and endothelin (ET-1). An imbalance between NO and ET-1 may contribute to the alterations in vascular tone characteristic of cardiovascular disease. The objective of thi