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Regulation of endothelial cell myosin light chain phosphorylation and permeability by vanadate

✍ Scribed by Lydia I. Gilbert-McClain; Alexander D. Verin; Shu Shi; Robert P. Irwin; Joe G.N. Garcia

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 213 KB
Volume: 70
Category: Article
ISSN: 0730-2312
DOI: 10.1002/(sici)1097-4644(19980701)70:1<141::aid-jcb14>3.0.co;2-s

No coin nor oath required. For personal study only.

✦ Synopsis

The involvement of tyrosine protein phosphorylation in the regulation of endothelial cell (EC) contraction and barrier function is poorly understood. We have previously shown that myosin light chain (MLC) phosphorylation catalyzed by a novel 214 kDa EC myosin light chain kinase (MLCK) isoform is a key event in EC contraction and barrier dysfunction [Garcia et al.

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