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Regulation of endorphin production by glucocorticoids in cultured pituitary tumor cells

โœ Scribed by Steven L. Sabol


Book ID
118312572
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
454 KB
Volume
82
Category
Article
ISSN
0006-291X

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Rat 235-1 pituitary tumor cells are lactotrophs producing high levels of prolactin (PRL). Dexamethasone (Dex, 100 nM) inhibits PRL gene expression in 235-1 cells by 50%, while simultaneously decreasing cell replication and cell-cell aggregation. To determine the time course of Dex action, we used a