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Regulation of EGF-receptor (EGFR) in the gastric mucosa during aging and carcinogenesis by ERRP, a novel negative regulator of EGFR

✍ Scribed by Majumdar, Adhip P.N.; Du, Jianhua; Nagothu, Kiran K.; Hatfield, James; Levi, Edi; Adsay, Volkan; Schmelz, Eva M.; Rishi, Arun K.; Jaszewski, Richard; Kucuk, Omer; Sarkar, Fazlul


Book ID
122938958
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
176 KB
Volume
124
Category
Article
ISSN
0016-5085

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## Abstract In this study, we demonstrated that tyrosine phosphorylation of EGFR and the autocrine expression of uPA and HB‐EGF depend on the activity of c‐jun amino‐terminal kinase (JNK) in human prostatic DU‐145 cells. These cells overexpress EGFR and produce a high amount of uPA. Treatment with