Regulation of dissolution rate by pellet geometry

✍ Scribed by E. G. Rippie; J. R. Johnson

• Book ID: 102396421
• Publisher: John Wiley and Sons
• Year: 1969
• Tongue: English
• Weight: 453 KB
• Volume: 58
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600580408

✦ Synopsis

The influence of surface configuration on the dissolution behavior of pellets suspended in a turbulent flow field has been investigated. The rate of dissolution of extruded cellulose acetate hydrogen phthalate pellets was found to be a complex function of surface geometry. The study was undertaken to determine the in uitro sustained release characteristics of pellets of a form such that their loss of effective surface area during dissolution is minimized. Factors involved in the design of such pellets are discussed and data are presented which indicate the dissolution characteristics of test forms.

Keyphrases 0 Dissolution rate-pellet geometry effect 0 Extrusion process-pellet formation 0 Pellet surface area-dissolution effect Colorimetric analysis-spectrophotometer