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Regulation of cytoplasmic pH in lymphocytes: Possible role of Na+/H+ exchange in mitogenesis

✍ Scribed by S. Grinstein; S. Cohen

Book ID
119049882
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
44 KB
Volume
27
Category
Article
ISSN
0090-6980

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Two distinct mechanisms have been shown to mediate cytoplasmic p H (pH,) recovery in acid-loaded peritoneal macrophages (M+s): Na+/H+ exchange and H + extrusion by vacuolar-type (V-type) H+ ATPases. The present studies examined the relative roles of these two systems in maintaining pH, and cell func