Regulation of Cytochrome P450 Expression in a Novel Liver Cell Line from Zebrafish (Brachydanio rerio)
β Scribed by C.L. Miranda; P. Collodi; X. Zhao; D.W. Barnes; D.R. Buhler
- Book ID
- 115564608
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 826 KB
- Volume
- 305
- Category
- Article
- ISSN
- 0003-9861
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Cytochrome P450 aromatase (CYP19) is the terminal enzyme in the steroidogenic pathway that converts androgens (e.g., testosterone) into estrogens (e.g., estradiol). Regulation of this gene dictates the ratio of androgens to estrogens; therefore, appropriate expression of this enzyme is
Cytochrome P450 is known to cause carcinogen activation and correspondingly increased cancer risk in animal models. In order to determine whether P450 in the colon may be involved in cancer development in the human, the human colon cell line LS174T was examined for the presence of various cytochrome