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Regulation of cyclic GMP levels in the rat frontal cortex in vivo: effects of exogenous carbon monoxide and phosphodiesterase inhibition

✍ Scribed by Kirsti S.M. Laitinen; Kari Salovaara; Silvia Severgnini; Jarmo T. Laitinen

Book ID
114002491
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
226 KB
Volume
755
Category
Article
ISSN
0006-8993

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## Abstract We have characterized the various phosphodiesterases (PDE) that degrade cyclic GMP in the prefrontal cortex, hippocampus, and cerebellum using the microdialysis technique to measure in vivo extracellular cyclic GMP in awake rats. The following PDE blockers were used (100 and 1,000 ΞΌM):