Regulation of constitutive STAT5 phosphorylation in acute myeloid leukemia blasts
β Scribed by Birkenkamp, KU; Geugien, M; Lemmink, HH; Kruijer, W; Vellenga, E
- Book ID
- 110055071
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 478 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0887-6924
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## Abstract In chronic myeloid leukemia (CML), the transforming activity of Bcr/Abl involves constitutive activation of the phagocyte specific Srcβfamily tyrosine kinase Hck, which in turn directly activates the signal transducer and activator of transcription 5 (STAT5). The effect of Hck on STAT5