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Regulation of Claspin degradation by the ubiquitin-proteosome pathway during the cell cycle and in response to ATR-dependent checkpoint activation

โœ Scribed by Lara N. Bennett; Paul R. Clarke


Book ID
116466816
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
550 KB
Volume
580
Category
Article
ISSN
0014-5793

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## Abstract Previous work showed a genetic control of cell cycle deregulation during hepatocarcinogenesis. We now evaluated in preneoplastic lesions, dysplastic nodules and hepatocellular carcinoma (HCC), chemically induced in genetically susceptible F344 and resistant Brown Norway (BN) rats, the r