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Regulation of cholinergic gene expression by nerve growth factor depends on the phosphatidylinositol-3′-kinase pathway

✍ Scribed by Beata Madziar; Ignacio Lopez-Coviella; Victoria Zemelko; Brygida Berse

Book ID
111178678
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
666 KB
Volume
92
Category
Article
ISSN
0022-3042

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Growth arrest of PC12 cells by nerve growth factor is dependent on the phosphatidylinositol 3-kinase/Akt pathway via p75 neurotrophin receptor
✍ Hisanori Ito; Hiroshi Nomoto; Shoei Furukawa 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 127 KB

## Abstract We recently isolated mutant PC12 cell clones (PC84 cells) by transfection of PC12 cells with nerve growth factor (NGF) cDNA. These cells secreted active NGF and extended short processes, but proliferated faster than the parental PC12 cells. Because the expression level of p75, a low‐aff