✦ LIBER ✦

Regulation of cell-type-specific transcription and differentiation of the pituitary

✍ Scribed by Z. Dave Sharp; Zhaodan Cao

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 787 KB
Volume: 12
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950120206

No coin nor oath required. For personal study only.

✦ Synopsis

The transcription of rat prolactin and growth hormone genes in vitro requires a pituitary transcription factor, specific to certain cell types in the pituitary, which currently appears to be the PUF-I/Pit-l/GHF-l protein. This factor binds to cis-regulatory elements in the 5' region of both genes and exerts a positive influence on transcription initiation presumably by interacting with general transcription factors. The PUF-I/F'it-l/GHF-l transcriptional regulatory protein probably has an important role in not only the differentiation of the pituitary lactotroph/somatotroph cell lineage; it is also expressed in the early development of the nervous system but its function there is less well documented. It appears to be one member of a family of trans-activator proteins involved in differential gene expression in several cell types.

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