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Regulation of C6 glioma cell steroidogenesis by adenosine 3′,5′-cyclic monophosphate

✍ Scribed by Dr. Vassilios Papadopoulos; Patrizia Guarneri

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
370 KB
Volume
10
Category
Article
ISSN
0894-1491

No coin nor oath required. For personal study only.

✦ Synopsis

Incubation of C6 glioma cells in the presence of aminoglutethimide, an inhibitor of cholesterol metabolism, together with either adenosine 3',5'-cyclic monophosphate (CAMP) analogues or agents that increase CAMP synthesis, such as cholera toxin, forskolin, and isoproterenol, stimulated the rate of pregnenolone formation by their isolated mitochondria. This effect of CAMP was blocked by the antagonist (Rp)-CAMPS. The incorporation rate of mevalonolactone into pregnenolone was also increased by the stimulation of adenylyl cyclase activity in intact C6 cells. It is concluded that CAMP stimulates glial cell steroidogenesis by increasing the movement of the substrate, cholesterol, to the mitochondria, where it will be metabolized to pregnenolone by the side

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