We examined the effects of feeding deoxycholic acid (1% and 0.4% of diet), alone and in combination with ursodeoxycholic acid, on serum and biliary bile acid concentrations, hepatic morphology, and the activities and steady-state messenger RNA (mRNA) levels of HMG-CoA reductase and cholesterol 7a-hy
✦ LIBER ✦
Regulation of bile acid synthesis in humans: Effect of treatment with bile acids, cholestyramine or simvastatin on cholesterol 7α-hydroxylation rates in vivo
✍ Scribed by Marco Bertolotti; Nicola Abate; Paola Loria; Michele Dilengite; Francesca Carubbi; Adriano Pinetti; Antonia Dlgrisolo; Nicola Carulli
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 886 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0270-9139
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The gene encoding cholesterol 7␣-hydroxylase (CYP7A1) is tightly regulated to control bile acid synthesis and maintain lipid homeostasis. Recent studies in mice suggest that bile acid synthesis is regulated by the fasted-to-fed cycle, and fasting induces CYP7A1 gene expression in parallel to the ind