Regulation of autocrine fibroblast growth factor-2 signaling by perfusion flow in 3D human mesenchymal stem cell constructs

Induction of stromelysin-1 (MMP-3) by fi

Induction of stromelysin-1 (MMP-3) by fibroblast growth factor-2 (FGF-2) in FGF-2−/− microvascular endothelial cells requires prolonged activation of extracellular signal-regulated kinases-1 and -2 (ERK-1/2)

✍ Giuseppe Pintucci; Pey-Jen Yu; Ram Sharony; F. Gregory Baumann; Fiorella Saponar 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 271 KB

## Abstract Basic fibroblast growth factor (FGF‐2) and matrix metalloproteinases (MMPs) play key roles in vascular remodeling. Because FGF‐2 controls a number of proteolytic activities in various cell types, we tested its effect on vascular endothelial cell expression of MMP‐3 (stromelysin‐1), a br