Regulation of antibody synthesis in the X-irradiated Mexican axolotl

✍ Scribed by Jacques Charlemagne

• Publisher: John Wiley and Sons
• Year: 1981
• Tongue: English
• Weight: 503 KB
• Volume: 11
• Category: Article
• ISSN: 0014-2980
• DOI: 10.1002/eji.1830110909

✦ Synopsis

Abstract

The effects of X‐irradiation were studied on the Mexican axolotl antibody synthesis. To reduce the anti‐horse red blood cell (HRBC) antibody titers, 150 rd and smaller doses are ineffective, 200–450 rd are increasingly effective, and 700 rd are maximally effective (and lethal). A significant enhancement of the anti‐HRBC titers was observed in low doses (50–150 rd X‐irradiated animals). This enhancement was also observed when a low X‐ray dose was applied only on the thymic areas. In whole body, but thymus area‐shielded, 100 rd X‐irradiated animals, the anti‐HRBC titers were similar to those of the nonirradiated, HRBC‐immunized control group. To explain these phenomena, it is suggested that a radiosensitive, adult thymectomy‐sensitive and hydrocortisone‐sensitive suppressor T cell subpopulation regulates the antibody synthesis in the axolotl.