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Regulation of Alternative Pathway Complement Activation by Glycosaminoglycans: Specificity of the Polyanion Binding Site on Factor H

✍ Scribed by S. Meri; M.K. Pangburn

Book ID
115574043
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
435 KB
Volume
198
Category
Article
ISSN
0006-291X

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Activation of the alternative pathway of
Activation of the alternative pathway of complement: efficient fluid-phase amplification by blockade of the regulatory complement protein Ξ²1H through sulfated polyanions
✍ Dieter Bitter-Suermann; Reinhard Burger; Ulrich Hadding πŸ“‚ Article πŸ“… 1981 πŸ› John Wiley and Sons 🌐 English βš– 584 KB

## Abstract Current concepts of activation of the alternative pathway of complement (APC) focus on the central role of an amplification mechanism triggered by C3b which is covalently bound to the surface of activating substances. Using sulfated polyanions as model substances, an efficient fluid‐pha