Regulation of acetylcholine receptor function by the phorbol ester TPA in rat skeletal muscle
โ Scribed by C. G. Caratsch; F. Knoffach; F. Grassi; F. Eusebi
- Book ID
- 112275545
- Publisher
- Springer-Verlag
- Year
- 1989
- Tongue
- English
- Weight
- 605 KB
- Volume
- 340
- Category
- Article
- ISSN
- 0028-1298
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As has been observed with many types of cultured cells, chicken embryo fibroblasts (CEF) when exposed to the tumor promoter 12-0-tetradecanoylphorbol-13-acetate (TPA) develop a 3-to 4-fold increase in hexose transport activity in 4 h. This increase in transport activity occurred despite a modest dec
## Abstract Using a calpain/protein kinase C (PKC) complex, we were able to reproduce, __in vitro__, the induction of PKC downโregulation by the phorbol ester 12โOโtetradecanoylโphorbolโ13โacetate (TPA) which had been previously observed in cells. We show that TPA initiates this phenomenon by promo