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Regulation of a volume-sensitive anion channel in rat pancreatic β-cells by intracellular adenine nucleotides

✍ Scribed by Helen E. Miley; Peter D. Brown; Leonard Best

Book ID
111118881
Publisher
Cambridge University Press
Year
1999
Tongue
English
Weight
228 KB
Volume
515
Category
Article
ISSN
0022-3751

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ATP-inhibited potassium channels (K(ATP)) were studied in excised, inside-out patches from cultured adult mouse pancreatic beta-cells and HIT cells. In the absence of ATP, ADP opened K(ATP) channels at concentrations as low as 10 microM and as high as 500 microM, with maximal activation between 10 a