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Regulation of 3-hydroxy-3-methylglutarate and mevalonate biosynthesis by rat liver homogenates. Effects of fasting, cholesterol feeding, and triton administration

✍ Scribed by White, Lawrence W.; Rudney, Harry


Book ID
126450468
Publisher
American Chemical Society
Year
1970
Tongue
English
Weight
726 KB
Volume
9
Category
Article
ISSN
0006-2960

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Cytosolic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase catalyzes the formation of HMG-CoA, the substrate for the rate-controlling enzyme in the cholesterol biosynthetic pathway. To explore the regulation in liver, we developed a new, accurate, and reliable reversed-phase ion-pair chromat