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Regulation of 2′,5′-oligo(A) synthetase activity in theophylline-treated NIH 3T3 cells

✍ Scribed by A.V. Itkes; K.T. Turpaev; O.N. Kartasheva; V.L. Tunitskaya; C.A. Kafiani; E.S. Severin

Book ID
115915359
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
277 KB
Volume
166
Category
Article
ISSN
0014-5793

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Cyclic AMP-dependent regulation of activities of synthetase and phosphodiesterase of 2′,5′-oligoadenylate in NIH 3T3 cells
✍ Alexander V. Itkes; Kyril T. Turpaev; Olga N. Kartasheva; Constantin A. Kafiam; 📂 Article 📅 1984 🏛 Springer 🌐 English ⚖ 456 KB

Treatment of NIH 3T3 cells with adenylate cyclase activator adrenaline (10(-6) M) or cAMP phosphodiesterase inhibitor theophylline (10(-3) M) was shown to lead to intracellular cAMP elevation followed by a 2.0-to 2.5-fold increase in the 2',5'-oligoadenylate synthetase activity. This process was blo