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Regulating the regulator: post-translational modification of RAS

✍ Scribed by Ahearn, Ian M.; Haigis, Kevin; Bar-Sagi, Dafna; Philips, Mark R.

Book ID: 109959663
Publisher: Nature Publishing Group
Year: 2011
Tongue: English
Weight: 832 KB
Volume: 13
Category: Article
ISSN: 1471-0072
DOI: 10.1038/nrm3255

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## Abstract Protease‐activated receptors (PARs) are a unique family of G‐protein‐coupled receptors (GPCRs) that are irreversibly activated following proteolytic cleavage of their extracellular N‐terminus. PARs play critical functions in hemostasis, thrombosis, inflammation, embryonic development, a