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Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

✍ Scribed by Toledo, Franck; Wahl, Geoffrey M.


Book ID
109947748
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
977 KB
Volume
6
Category
Article
ISSN
1474-1776

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## Abstract The amino terminus truncated p73 isoform, Ξ”Np73Ξ±, shows dominant negative behavior toward TAp73 and wild‐type p53, and has oncogenic potential. By contrast, we recently showed that in HCT116 clones forced expression of Ξ”Np73Ξ± did not increase __in vitro__ cellular resistance to anticanc