𝔖 Bobbio Scriptorium
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Regulating gene expression in transgenic animals

✍ Scribed by Catherine A. Kappel; Simon Xin-Min Zhang; Charles J. Bieberich; Gilbert Jay

Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
673 KB
Volume
3
Category
Article
ISSN
0958-1669

No coin nor oath required. For personal study only.

✦ Synopsis

Regardless of the field of application, the raison d'etre of transgenic animals is to study gene regulation and function. With increasing frequency, mammalian genes are being isolated with no concomitant knowledge of their function. The human genome mapping initiative will undoubtedly produce a cornucopia of such genes. While the merit of taking a transgenic route to study genes of unknown function is axiomatic, the choices of strategies for gene regulation in vivo may not be fully appreciated. This review will address two main points: first, the targeted and regulated expression of genes, and second, the structural and functional ablation of genes.

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## Background: The combination of physiologically and pharmacologically controlled elements may provide a means to ensure both the regulation and the safety of transgene expression--two major goals in gene therapy. ## Methods: A two-gene modulation system was developed that uses the following thr