Regulating self-tolerance by deregulatin
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JΓΆrn Gotter; Bruno Kyewski
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Article
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2004
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Elsevier Science
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English
β 102 KB
Intrathymic expression of peripheral auto-antigens, termed promiscuous gene expression, extends the scope of central T-cell tolerance to peripheral organs and proves essential for the induction and maintenance of self-tolerance. The purification of antigen-presenting cells has been instrumental in i