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Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

✍ Scribed by Heather P Harding; Isabel Novoa; Yuhong Zhang; Huiqing Zeng; Ron Wek; Matthieu Schapira; David Ron

Book ID
117735973
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
658 KB
Volume
6
Category
Article
ISSN
1097-2765

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Protein kinases that phosphorylate the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha) are activated in stressed cells and negatively regulate protein synthesis. Phenotypic analysis of targeted mutations in murine cells reveals a novel role for eIF2alpha kinases in regulating gene expres

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