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Regulated proteolysis of the IFNaR2 subunit of the interferon-alpha receptor

✍ Scribed by Saleh, Abu Z M; Fang, Aaron T; Arch, Allison E; Neupane, Divas; Fiky, Ashraf El; Krolewski, John J

Book ID
110069023
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
412 KB
Volume
23
Category
Article
ISSN
0950-9232

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## Abstract We recently demonstrated that IFNaR2, a subunit of the interferon receptor, can be proteolytically cleaved in response to interferon‐alpha and other activators of protein kinase C. Cleavage occurs at multiple sites, via a mechanism similar to that employed by Notch and the Alzheimer's p