Regression of established methylcholanthrene tumors by intratumor injections of vibrio cholerae neuraminidase

✍ Scribed by Richard L. Simmons; Angelyn Rios; Prasanta K. Ray

• Book ID: 102437452
• Publisher: John Wiley and Sons
• Year: 1972
• Tongue: English
• Weight: 412 KB
• Volume: 4
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930040403

✦ Synopsis

Methylcholanthrene fibrosarcomas were transplanted into syngeneic C3WHeJ mice. When the tumors had become firmly established and were palpable, injections of Vibrio cholerae neuraminadase were made directly into the tumor mass. Growth generally stopped in the injected tumors and a number of tumors totally regressed. In animals bearing bilaterial immunologically identical tumors, injection of one tumor with Vibrio cholerae neuraminidase induced the regression not only of the injected tumor, but also of the contralateral tumor. When the bilateral tumors were of different types, injections of one did not lead to regression of the other but the animals were still capable of rejecting the injected tumor while dying of the immunodistinct untreated tumor.

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