Chronic medical conditions are often manifested by the incidence of recurrent adverse clinical events. In clinical trials designed to investigate therapeutic interventions for such conditions it is natural to make treatment comparisons on the basis of event occurrence. However, when there is a more
β¦ LIBER β¦
Regression analysis of multivariate recurrent event data with a dependent terminal event
β Scribed by Liang Zhu; Jianguo Sun; Xingwei Tong; Deo Kumar Srivastava
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 257 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1380-7870
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Exploration of the variation of treatment effect over time in randomized clinical trials with low event rates is limited by lack of power. A meta-analysis on individual patient data from such trials can partly solve the problem, but brings other computational difficulties. Using an example in hypert