Regressing nude mouse grafts of burkitt's lymphoma×lymphoblastoid cell hybrids show deregulation of the c-myc gene and expression of the EBV latent membrane protein
✍ Scribed by Jürgen Wolf; Britta Klevenz; Michael Pawlita; Dimitrij Komitowski; Gerd Moldenhauer; Harald Zur Hausen
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- French
- Weight
- 833 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Somatic cell hybrids between the malignant Burkitt lymphoma cell line BL 60 and the non-malignant Epstein-Barr virus EBV) immortalized lymphoblastoid cell line (LCL) pattern of the parental BL cell line during exponential growth in tissue culture. Subcutaneous nude mouse grafts of these hybrids, however, completely regress after an initial growth phase. To investigate whether regression of these grafts is mediated by a down-regulation of the BL-60-derived deregulated c-myc gene in vivo, c-myc transcription was analyzed in growing versus regressing hybrid grafts. In the initial growth