Regiospecific tritium labeling of aromatic acids, amides, amines and heterocyclics using homogeneous rhodium trichloride and ruthenium acetylacetonate catalysts

✍ Scribed by David Hesk; John R. Jones; William J. S. Lockley

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: French
• Weight: 366 KB
• Volume: 28
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580281211

✦ Synopsis

Abstract

Homogeneous rhodium trichloride has been found to promote ortho‐tritiation with high regioselectivity in a wide range of aromatic carboxylic acids, amides and aralkylamines. Less successful results were obtained using o‐chlorobenzoic and o‐anisic acids where some decomposition was seen, and in acids and amides of the phenolic type, where a degree of electrophilic exchange accompanies the ortho‐exchange. The same catalyst has also been used to regiospecifically label a number of heterocyclics. In the course of investigations with other metal complexes ruthenium acetylacetonate has been identified as an excellent promoter of ortho‐exchange in benzoic acids.