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Regiospecific one-pot synthesis of new trifluoromethyl substituted heteroaryl pyrazolyl ketones

✍ Scribed by Helio G. Bonacorso; Marli R. Oliveira; Michelle B. Costa; Letícia B. Da Silva; Arci D. Wastowski; Nilo Zanatta; Marcos A. P. Martins

Publisher
Journal of Heterocyclic Chemistry
Year
2005
Tongue
English
Weight
85 KB
Volume
42
Category
Article
ISSN
0022-152X

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✦ Synopsis

A convenient and general method for the regiospecific synthesis of three novel series of 1-(2-thenoyl)-, 1-(2furoyl)-and 1-(isonicotinoyl)-3-alkyl(aryl)-5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-pyrazoles, in good yields (53 -91 %), from the cyclocondensation reactions of 1,1,1-trifluoro-4-alkoxy-4-alkyl(aryl)-but-3-en-2ones, where alkyl = H and Me; aryl = -C

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