Regiospecific synthesis of 4-substituted pyridines is attained y& alkylation of diisopropyl 1-ethoxycarbonyl-1, 4-dihydropyridine-4-phosphonate followed by treatment with butyllithium. The phosphonate is prepared directly from pyridine in one pot. Considerable efforts have been made to introduce sub
Regiospecific .alpha.-alkylation of 4-chloro(bromo)pyridine
β Scribed by Comins, Daniel L.; Mantlo, Nathan B.
- Book ID
- 125432153
- Publisher
- American Chemical Society
- Year
- 1985
- Tongue
- English
- Weight
- 301 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
The title compound, C 7 H 6 BrClO, is a starting material for the synthesis of hydroxylated metabolites of polychlorinated biphenyls (PCBs). The title compound does not display any unusual bond distances and angles. The methoxy group is rotated slightly out of the plane of the benzene ring.
The title compound, C 10 H 8 BrNS, is used as a precursor to diarylethene derivatives. The dihedral angle between the thiophene and pyridine rings is 4.9 (1) , and there is evidence for conjugation throughout the molecule. The structure is stabilized bystacking interactions down the c axis.