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Regiospecific aldol condensations of the kinetic lithium enolates of methyl ketones

โœ Scribed by Stork, Gilbert; Kraus, George A.; Garcia, Gustavo A.


Book ID
120218811
Publisher
American Chemical Society
Year
1974
Tongue
English
Weight
273 KB
Volume
39
Category
Article
ISSN
0022-3263

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Threo-selective aldol condensations of l
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The reaction of preformed lithium enolates in the presence of trialkylboranes, such as Et3B and n-Bu3B, with aldehydes leads to product mixtures rich in the more stable threo aldol. The development of the diastereoselective synthesis of t3-hydroxycarbonyl compounds as a basic synthetic block for ma