✦ LIBER ✦
Regiospecific Acylation, Alkylation, and Aldol Condensation using magnesium enolates resulting from the conjugate addition of grignard reagents to α, β-unsaturated ketones
✍ Scribed by Ferdinand Näf; René Decorzant
- Publisher
- John Wiley and Sons
- Year
- 1974
- Tongue
- German
- Weight
- 709 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
The magnesium 3,3‐dimethylcyclohex‐1‐enolate 1i, formed in the copper catalyzed addition of methylmagnesium iodide to 3‐methylcyclohex‐2‐enone, has been subjected to regiospecific electrophilic reactions such as acylation, alkylation, and aldol condensation in order to find a new access to the damascones, ionones and carotenoids. By way of illustration a new synthesis of γ‐damascone is described.