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Regiospecific [2+2] cycloadditions of electron-poor acetylenes to (Z)-2-acylamino-3-dimethylaminopropenoates: synthesis of highly functionalised buta-1,3-dienes

✍ Scribed by Uroš Uršič; Uroš Grošelj; Anton Meden; Jurij Svete; Branko Stanovnik


Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
220 KB
Volume
49
Category
Article
ISSN
0040-4039

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[2+2] Cycloaddition of electron-poor ace
✍ Jure Bezenšek; Tanja Koleša; Uroš Grošelj; Jernej Wagger; Katarina Stare; Anton 📂 Article 📅 2010 🏛 Elsevier Science 🌐 French ⚖ 727 KB

2en-1-ones 1-Heteroaroyl-1,3-butadienes a b s t r a c t Microwave-assisted [2+2] cycloaddition of (E)-3-dimethylamino-1-heteroaryl-prop-2-en-1-ones to dimethyl acetylenedicarboxylates gives (2E,3E)-dimethyl-2-[(dimethylamino)methylene]-3-(substituted)succinates in 8-91% yield. In the case of a 4,5-d