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Regioselectivity Control in the Metal-Catalyzed Functionalization of γ-Allenols, Part 2: Theoretical Study

✍ Scribed by Benito Alcaide; Pedro Almendros; Teresa Martínez del Campo; Elena Soriano; José L. Marco-Contelles


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
952 KB
Volume
15
Category
Article
ISSN
0947-6539

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Regioselectivity Control in the Metal-Ca
✍ Benito Alcaide; Pedro Almendros; Teresa Martínez del Campo; Elena Soriano; José  📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 312 KB

## Abstract Guiding cyclization: The 5‐__exo‐trig__ cyclization pathway of γ‐allenols can be completely reversed either by changing the metal (Pd instead of Au) or by using a methoxymethyl protecting group, with 7‐__endo‐trig__ alkoxycyclization then dominating instead (see scheme). In addition, th