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Regioselective synthesis of pyrimido[5,4-c][2,1]benzothiazines by reactions of β-chloroaldehydes with n-c-n binucleophiles

✍ Scribed by Kirill Popov; Tatyana Volovnenko; Alexander Turov; Yulian Volovenko

Publisher: Journal of Heterocyclic Chemistry
Year: 2009
Tongue: English
Weight: 162 KB
Volume: 47
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.271

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✦ Synopsis

Abstract

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The method of pyrimidine ring fusion at the [c] side of benzothiazines based on the reaction of their chloroaldehyde derivatives with amidines is described. Formation of the structural isomers of reaction products was investigated, and regioselectivity of heterocyclization reactions was shown. A number of novel pyrimidobenzothiazines were synthesized. J. Heterocyclic Chem., 2010.

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