Regioselective synthesis of heterocyclic scaffold by aryl radical cyclization

✍ Scribed by K. C. Majumdar; N. Kundu

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2008
• Tongue: English
• Weight: 397 KB
• Volume: 45
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570450414

✦ Synopsis

Abstract

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Regioselective synthesis of a number of coumarin‐annulated pentacyclic heterocycles have been achieved by tri‐n‐butyltin hydride‐mediated aryl radical cyclization. The products are formed as a mixture of cis‐ and trans‐ forms which were successfully separated by careful silica gel flash chromatography.