✦ LIBER ✦

Regioselective synthesis of folate receptor-targeted agents derived from epothilone analogs and folic acid

✍ Scribed by Iontcho R. Vlahov; Gregory D. Vite; Paul J. Kleindl; Yu Wang; Hari Krishna R. Santhapuram; Fei You; Stephen J. Howard; Soong-Hoon Kim; Francis F.Y. Lee; Christopher P. Leamon

Book ID: 104004499
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 467 KB
Volume: 20
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.06.016

No coin nor oath required. For personal study only.

✦ Synopsis

Scheme 1. Scheme 2. Reagents and conditions: (a) 2-bromoethanol, K 2 CO 3 , acetonitrile, 80 °C; (b) TFA/CH 2 Cl 2 ; (c) 5, DMAP, CH 2 Cl 2 ; (d) 2, H 2 O, THF.

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