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Regioselective synthesis of bioactive spiro heterocyclic compounds containing both indoline and quinolone moieties by aryl radical cyclization

✍ Scribed by K. C. Majumdar; N. Kundu

Publisher
Journal of Heterocyclic Chemistry
Year
2009
Tongue
English
Weight
109 KB
Volume
46
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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The tin hydride‐mediated aryl radical cyclization of a number of 4‐(2′‐bromo‐N‐methylanilino)methyl‐1‐alkylquinolin‐2(1__H__)‐ones under mild neutral condition afforded 1‐alkyl‐3,4‐dihydroquinolin‐2(1__H__)‐one‐4‐spiro‐3′‐(1‐methylindolines) in excellent yield. The starting materials, amines were derived from 4‐bromomethyl‐N‐methyl quinolin‐2(1__H__)‐ones and 2‐bromo‐N‐methyl anilines by refluxing in acetone in the presence of anhydrous potassium carbonate and sodium iodide (Finkelstein condition). J. Heterocyclic Chem., 46, 492 (2009).

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ChemInform Abstract: Regioselective Synt
ChemInform Abstract: Regioselective Synthesis of Bioactive Spiro Heterocyclic Compounds Containing Both Indoline and Quinolone Moieties by Aryl Radical Cyclization.
✍ K. C. Majumdar; N. Kundu 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 23 KB 👁 1 views

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