Regioselective substitution of 2,3-dichloro-6-amino-quinoxaline
✍ Scribed by Emma Ford; Andy Brewster; Geraint Jones; John Bailey; Neil Sumner
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 76 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The novel regioselective substitution of 2,3-dichloro-6-amino-quinoxaline is described. A range of nucleophiles were used to provide 2,3-disubstituted-6-aminoquinoxalines with complementary regiochemistry to that obtainable using published methodology.
📜 SIMILAR VOLUMES
The title compound, C 16 H 6 Br 2 Cl 2 N 2 S 2 , was synthesized from the reaction of equimolar amounts of 1,2-diamino-4,5dichlorobenzene and 1,2-bis(5-bromothien-2yl)ethanedione. The crystal structure was determined at 100 K.
## Abstract The hydrolysis of the 2‐substituted 4,6‐dichloro‐1,3,5‐triazines was investigated in a mixture of water and acetone. The reaction constant of the hydrolysis of the first chlorine atom was determined, and is discussed in relation to the structure of the triazine derivatives.
In the title compound, [Fe(C 5 H 5 )(C 17 H 10 Cl 2 N 3 )], the planes of the substituted cyclopentadienyl and benzene rings make dihedral angles of 14.3 (2) and 87.2 (1) , respectively, with the pyridine ring.