✦ LIBER ✦

Regioselective phosphorylation of vicinal 3,4-hydroxy myo-inositol derivative promoted practical synthesis of d-PtdIns(4,5)P2 and d-Ins(1,4,5)P3

✍ Scribed by Fushe Han; Minoru Hayashi; Yutaka Watanabe

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 304 KB
Volume: 59
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(03)01212-2

No coin nor oath required. For personal study only.

✦ Synopsis

The reactivity of 3 and 4-OH in 3,4-diol myo-inositol derivatives were observed through the phosphorylation, acylation and silylation. The results indicated that 3-OH is much more reactive than 4-OH, giving regiospecifically 3-mono-functionalized products. This investigation provided a concise methodology for the synthesis of natural D-form of PtdIns(4,5)P2 and D-Ins(1,4,5)P3 from L-1,2-Ocyclohexylidene-3,4-O-(tetraisopropyl disiloxane-1,3-diyl)-myo-inositol.

📜 SIMILAR VOLUMES

Regioselective Phosphorylation of Vicina

Regioselective Phosphorylation of Vicinal 3,4-Hydroxy myo-Inositol Derivative Promoted Practical Synthesis of D-PtdIns(4,5)P2 and D-Ins(1,4,5)P3.

✍ Fushe Han; Minoru Hayashi; Yutaka Watanabe 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 70 KB 👁 1 views

ChemInform Abstract: A Convenient Synthe

ChemInform Abstract: A Convenient Synthesis of D-myo-Inositol 1,4,5-Trisphosphate (Ins(1,4,5)P3) and L-myo-Inositol 1,4,5-Trisphosphate (Ins(3,5,6)P3).

✍ L. W. LEUNG; R. BITTMAN 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB 👁 2 views

Synthesis of D- and L-myo-Inositol 1,2,4

Synthesis of D- and L-myo-Inositol 1,2,4,6-Tetrakisphosphate, Regioisomers of myo-Inositol 1,3,4,5-Tetrakisphosphate: Activity Against Ins(1,4,5)P3 Binding Proteins.

✍ Stephen J. Mills; Katrien Backers; Christophe Erneux; Barry V. L. Potter 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 55 KB 👁 2 views

Regioselective synthesis of photolabile

Regioselective synthesis of photolabile P(1,2)- and P(4,5)-(o-nitrobenzyl) esters of myo-inositol 1,2,3,4,5,6-hexakisphosphate

✍ Jian Chen; Glenn D. Prestwich 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 245 KB

ChemInform Abstract: Regioselective Synt

ChemInform Abstract: Regioselective Synthesis of Photolabile P(1,2)- and P(4,5)-(o- Nitrobenzyl) Esters of myo-Inositol 1,2,3,4,5,6-Hexakisphosphate.

✍ J. CHEN; G. D. PRESTWICH 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 26 KB 👁 1 views

ChemInform Abstract: Synthesis and Biolo

ChemInform Abstract: Synthesis and Biological Activity of D- and L-chiro-Inositol 2,3,4,5-Tetrakisphosphate: Design of a Novel and Potent Inhibitor of Ins(3,4,5,6)P4 1-Kinase/Ins(1,3,4)P3 5/6-Kinase.

✍ Changsheng Liu; Andrew M. Riley; Xiaonian Yang; Stephen B. Shears; Barry V. L. P 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 3 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v