𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Regioselective oxidation of indole- and quinolinecarboxylic acids by cytochrome P450 CYP199A2

✍ Scribed by Toshiki Furuya; Kuniki Kino


Publisher
Springer
Year
2009
Tongue
English
Weight
299 KB
Volume
85
Category
Article
ISSN
1432-0614

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Multiplicity of n-heptane oxidation path
✍ MirosΕ‚aw M. Szutowski; Joseph S. Rakoto πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 155 KB

## Abstract Modeling, mutagenesis, and kinetic studies have demonstrated that the substrate‐binding site of cytochrome P450 is composed of multiple interactive regions that are capable of simultaneously binding two or more xenobiotics. Substrate molecules can interact with each other after docking.

Roles of phenylalanine at position 120 a
✍ Kazufumi Masuda; Keietsu Tamagake; Takashi Katsu; Fumihiro Torigoe; Keita Saito; πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 350 KB

## Abstract The roles of Phe‐120 and Glu‐222 in the oxidation of chiral substrates bunitrolol (BTL) and bufuralol (BF) by CYP2D6 are discussed. Wild‐type CYP2D6 (CYP2D6‐WT) oxidized BTL to 4‐hydroxybunitrolol (4‐OH‐BTL) with substrate enantioselectivity of (__R__)‐(+)‐BTL > (__S__)‐(βˆ’)‐BTL. The sam