Regioselective oxidation of indole- and quinolinecarboxylic acids by cytochrome P450 CYP199A2
β Scribed by Toshiki Furuya; Kuniki Kino
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 299 KB
- Volume
- 85
- Category
- Article
- ISSN
- 1432-0614
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## Abstract The roles of Pheβ120 and Gluβ222 in the oxidation of chiral substrates bunitrolol (BTL) and bufuralol (BF) by CYP2D6 are discussed. Wildβtype CYP2D6 (CYP2D6βWT) oxidized BTL to 4βhydroxybunitrolol (4βOHβBTL) with substrate enantioselectivity of (__R__)β(+)βBTL > (__S__)β(β)βBTL. The sam