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Regioselective Lactonization of α-(2→8)-Trisialic Acid

✍ Scribed by Mou-Chi Cheng; Chun-Hung Lin; Kay-Hooi Khoo; Shih-Hsiung Wu

Book ID
101307267
Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
116 KB
Volume
38
Category
Article
ISSN
0044-8249

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✦ Synopsis

A simple and selective method has been developed to obtain both monolactones of the title compound, a model compound for biologically important polyneuraminic acid derivatives: acidic lactonization and alkaline hydrolysis of dilactone 1. The two monolactonized trimers can be separated by capillary electrophoresis, and then distinguished by enzymatic hydrolysis with neuraminidase; only the 2-monolactone undergoes reaction.

📜 SIMILAR VOLUMES

NMR studies of the reversible and regios
NMR studies of the reversible and regioselective lactonization of α-2,8-linked trisialic acid in aqueous acid
✍ Timothy Eckert; Chun-Ping Lu; Chien-Sheng Chen; Shih-Hsiung Wu; Jacquelyn Gervay 📂 Article 📅 2011 🏛 Elsevier Science 🌐 French ⚖ 288 KB

The pH dependent lactonization of trisialic acid was examined using NMR and CE techniques. The combined studies indicate that lactonization is a dynamic, pH dependent process that occurs with preferential lactonization between the carbonyl of the central residue and the reducing end C-9 hydroxyl gro

Regioselective Lactonization of Tetrasia
Regioselective Lactonization of Tetrasialic Acid
✍ Mou-Chi Cheng; Chun-Hung Lin; Hsiu-Yin Wang; Heng-Ru Lin; Shih-Hsiung Wu 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 395 KB 👁 1 views
Regioselective Lactonization of Tetrasia
Regioselective Lactonization of Tetrasialic Acid
✍ Mou-Chi Cheng; Chun-Hung Lin; Hsiu-Yin Wang; Heng-Ru Lin; Shih-Hsiung Wu 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 388 KB 👁 1 views

Polysialic acids (PSAs) are polymers of N-acetylneuraminic acid. Depending on their glycosidic linkages, these sugar polymers exist in nature as a-2,8-, a-2,9-, and a-2,8/2,9-linked polysaccharides. [1] PSAs have been reported to demonstrate many important biological functions. [2] For example, a-2,