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Regioselective deuterium labeling of 1,4-disubstituted-1,2,3,6-tetrahydropyridines

✍ Scribed by Stéphane Mabic; John M. Rimoldi; Neal Castagnoli Jr.


Publisher
John Wiley and Sons
Year
1997
Tongue
French
Weight
643 KB
Volume
39
Category
Article
ISSN
0022-2135

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Synthesis of 1,2,4-trisubstituted-1,2,5,
✍ Meng-Yang Chang; Ming-Fang Lee; Nien-Chia Lee; Yu-Ping Huang; Chung-Han Lin 📂 Article 📅 2011 🏛 Elsevier Science 🌐 French ⚖ 615 KB

A novel method for the synthesis of 1,2,4-trisubstituted-or 1,2,3,4-tetrasubstituted-1,2,5,6-tetrahydropyridine is presented. The process was carried out by the bromomethoxylation of 4-substituted-1,2,5,6-tetrahydropyridines 1 with N-bromosuccinimide (NBS) in methanol, dehydrobromination with 1,8-di