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Regioselective conversion of alkynes to 4-substituted and 3,4-disubstituted isoxazoles using titanium-catalyzed multicomponent coupling reactions

โœ Scribed by Amila A. Dissanayake; Aaron L. Odom


Book ID
113929139
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
1007 KB
Volume
68
Category
Article
ISSN
0040-4020

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One-pot preparation of 2-substituted and
โœ Xin Teng; Takeshi Wada; Sentaro Okamoto; Fumie Sato ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 70 KB

Sequential treatment of 2-alkynal tetramethylethylene acetals with a divalent titanium reagent Ti(O-i-Pr) 4 /2 i-PrMgX and aldehydes gave, after acidic work-up, furans in good to excellent yields, thus providing a new efficient one-pot access to a variety of 2-substituted and 2,3-disubstituted furan